Tobacco Asia

Tobacco Asia 35 ceptors within seconds and with a higher perceived strength. Typically, NicSelect T-Max at 8 mg/ml or 14 mg/ml seems to be ideal for most vapers, being perceived as 20 mg/ml or 40 mg/ml respectively. NicSelect T-Max at 20 mg/ml is perceived as 60 mg/ml or more, equally idea for the US or Russia where higher nicotine levels are common. The T-Max solution for a changing regulatory environment With an increasing number of countries restricting flavors and nicotine levels, NicSelect T-Max provides a new option. NicSe- lect T-Max is well appreciated by cigarette smokers and vapers alike as a flavorless e-liquid or with a light tobacco flavor. NicSe- lect T-Max also solves the dilemma with restriction on nicotine levels with a far higher perceived nicotine strength, 14 mg vapes like 40 mg and 20 mg like 60 mg. "Vapes just like a cigarette", hype or fact? The first indications that NicSelect T-Max was not hype came from an observational study we conducted in spring 2022 with 17 volunteers, dual users of traditional cigarettes and vaping products, comparing traditional e-liquids with different nicotine concentrations, finished e-liquids manufactured from NicSelect T-Max with different nicotine concentrations, and traditional cigarette. The results showed that NicSelect T-Max and ciga- rette were perceived as essentially similar in terms of nicotine intensity and speed of nicotine delivery compared to traditional vaping e-liquids. These results have been confirmed with testing days and demonstrations at Vape Expos and with one-on-one meetings with customers around the globe, T-Max truly "vapes just like a cigarette". About the Author: Anna Balconi is the Technical Manager at Alchem NicSelect, where she is responsible for the technical, regulatory and development aspects of nicotine products. She graduated in Biotechnology at the University of Milan and worked for several years in regulatory consultancy for the vaping industry before joining the Alchem NicSelect team in February 2021. About Alchem: Alchem International is a pioneer in the field of manufacturing high-quality active ingredients (APls) for the world's leading pharmaceutical, cosmetic and nutraceutical brands. The company's production sites are pharmaceutical ICHGMP rated and inspected by WHO, the US FDA and EDQM. Alchem International is the world's leading supplier of nicotine to the vaping, white nicotine pouch and Next Generation Nicotine Delivery (NGND) industry offering a range of primary materials to manufacturers of e-liquids, including pure nicotine EP, tobacco absolute, diluted nicotine bases, and nicotine salts. Study results Both traditional e-liquids and the e-liquids manufactured from NicSelect T-Max DbM have been proposed in the following nicotine concentrations: 4 mg/ml, 6 mg/ml, 8 mg/ ml, 9 mg/ml, and 12 mg/ml. The primary endpoints of the study involve the percep- tion of nicotine (intensity, speed, throat hit, satisfaction), in the three tested products and the participants have been asked to report their feedback on a questionnaire (Table 6). The data obtained from the questionnaire was processed and statistically analyzed using Student's t-test: the following figures show the results obtained in terms of Nicotine Intensity (Fig. 1), Throat Hit (Fig. 2), Speed of Perception (Fig. 3) and Overall Satisfaction (Fig. 4). Fig. 3 – Speed The speed of nicotine perception is non sig- nificantly different in the traditional cigarette (dark grey) and T-Max e-liquids (green), while it is significantly lower in traditional e- liquids (light grey), when compared to tradi- tional cigarette and T-Max e-liquid. *p<0,05; **p<0,01; ***p<0,001 vs traditional cigarette - °p<0,05; °°p<0,01; °°°p<0,001 vs "traditional e-liquids" Table 6 – Questionnaire distributed during study the trials Sponsored Post Fig. 1 – Nicotine intensity Nicotine intensity is perceived not significant- ly different in the traditional cigarette (dark grey) and in the T-Max e-liquids (green) and significantly less in traditional e-liquids (light grey), when compared to traditional cigarette and T-Max e-liquids. *p<0,05; **p<0,01; ***p<0,001 vs traditional cigarette - °p<0,05; °°p<0,01; °°°p<0,001 vs "traditional e-liquids" Fig. 2 – Throat Hit Throat hit is perceived as reduced in tradi- tional e-liquid (light grey) and T-Max e-liquid (green) compared with traditional cigarette (dark grey). Traditional e-liquids and T-Max e-liquids show no significant differences. *p<0,05; **p<0,01; ***p<0,001 vs traditional cigarette - °p<0,05; °°p<0,01; °°°p<0,001 vs "traditional e-liquids" Fig. 4 – Overall satisfaction The overall satisfaction is significantly higher in the traditional cigarette (dark grey) compared the other two products, but the T-Max e-liquids (green) show a level of satisfaction significantly higher than traditional e-liquids (light grey). *p<0,05; **p<0,01; ***p<0,001 vs traditional cigarette - °p<0,05; °°p<0,01; °°°p<0,001 vs "traditional e-liquids" Speed Nicotine Intensity Overall Satisfaction Throat Hit

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